Electrochemical selective annulative amino-ketalization and amino-oxygenation of 1,6-enynes

Xiao-Shuang Ji,¹ Hang-Dong Zuo,¹ Yi-Ting Shen, Wen-Juan Hao,* Shu-Jiang Tu* and Bo Jiang*

A new electrochemical selective annulative amino-ketalization and amino-oxygenation of 1,6-enynes with disulfonimides and alcohols is reported, producing a series of functionalized benzofurans under catalyst- and oxidant-free conditions. An annulative aminoketalization proceeds with simple short-chain alcohols such as methanol, ethanol and n-propanol as O-nucleophilic reagents while the reaction occurs in the annulative aminooxygenation direction in the presence of water and large steric sec-butyl alcohol (SBA).

Chem. Commun. 2022, 58, 10420-10423; DOI: 10.1039/D2CC03922B